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KMID : 1101320060380030218
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Korean Journal of Clinical Laboratory Science
2006 Volume.38 No. 3 p.218 ~ p.223
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An Association between Mitochondrial Enzyme Activity and Hearing Loss in Patients with Chronic Renal Failure
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Kim Eun-Sook
Ahn Seon-Ho
Kim Shin-Moo
So Hong-Seob
Park Rae-Kil
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Abstract
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Sensorineural hearing loss is frequently found in patients with chronic renal failure (CRF). There have been many efforts to elucidate the etiologic factors of hearing loss in patients with CRF. However, there was not any clear identified cause of hearing loss. This study was undertaken to evaluate the activity of mitochondrial respiratory chain (MRC) in CRF patients with hearing impairment. To determine MRC activity, peripheral blood cells were obtained from CRF patients with hearing impairment receiving dialysis and normal subjects without any hearing problems. MRC activity of complex I and complex III was measured by the Trounces method. In MRC activities between the normal subjects group and CRF patients with hearing problems, the complex I and III activities of CRF patients with hearing problems were 63% and 85% compared with normal subjects (p<0.01). These results suggest that the activity of MRC may be implicated in the underlying mechanism of the hearing impairment in CRF patients, through mitochondrial DNA mutations at MRC complex I region with a decrement of MRC activity.
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KEYWORD
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Hearing loss, Mitochondrial enzyme activity, Complex I, Complex III
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